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NIPT
Non Invasive Prenatal Test

When can I have this?

9+ weeks

What's included?

  • Trisomy 21 (Down syndrome), Trisomy 18 (Edwards syndrome), Trisomy 13 (Patau syndrome)
  • Harmony NIPT, Panorama NIPT & Neo 24 NIPT Tests Available
  • Sexing Option
  • From 9+ weeks
  • Test Results Securely Emailed
  • Scan Option
Regular Price £
*Price is dependent on specific NIPT test booked.
Terms and Conditions apply.

Book Now

Call Me

Locations

Award Winning First class service from multi award winning clinic. Trusted Our experts are trusted by midwives, doctors and many different health professionals Convenient Convenient appointments to fit your schedule with our experts Rated Excellent rating on Google and WhatClinic Featured Featured in multiple publications including Huffington Post.

NIPT
Non Invasive Prenatal Test

When can I have this?

9+ weeks

What's included?

  • Trisomy 21 (Down syndrome), Trisomy 18 (Edwards syndrome), Trisomy 13 (Patau syndrome)
  • Harmony NIPT, Panorama NIPT & Neo 24 NIPT Tests Available
  • Sexing Option
  • From 9+ weeks
  • Test Results Securely Emailed
  • Scan Option
 

 

Which NIPT tests do you offer?

We offer a number of leading and cutting edge Non Invasive Pre-natal Tests, including Harmony NIPT test, Neo 24 NIPT test and Panorama NIPT test. Further information about each of these tests is found below.

You can also discuss the different tests at your appointment with our specialist clinical staff and choose the one most suitable for you.

 

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What is NIPT and What will it show?

Non-invasive Prenatal Screening often shortened to NIPT is a type of screening test to see if there is a chance that your baby may be affected by certain common genetic disorders. The conditions include Down’s syndrome, Edwards’ syndrome and Pataus' syndrome. It is a non invasive test as it does not touch the fetus, placenta or amniotic fluid. Instead DNA from the fetus is collected from a sample of the mother's blood, like a typical routine blood test.

 

As a pregnant mother to be, you will have your own DNA in your bloodstream as well as the DNA of your unborn baby. Your babies DNA is found in your blood in the form of small fragments circulating around called cell-free DNA fragments (cfDNA). All NIPT tests will analyse this cfDNA to calculate a probability of your baby having one of the screened conditions, commonly Down’s syndrome (known as Trisomy 21), Edwards’ syndrome (known as Trisomy 18) and Patau’s syndrome (known as Trisomy 13).

 

NIPT testing is available from as early as 9 weeks pregnant. The Scan Clinic have partnered with the most trusted and leading NIPT Labs in the World in order to provide our patients the best possible NIPT test options available. 

 

What's Included:

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or

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What is the primary purpose of an NIPT test?

This test is performed to assess the risk of certain chromosomal conditions affecting the pregnancy. These conditions include Trisomy 21 (Down's syndrome), Trisomy 18 and Trisomy 13. The tests can also check the sex of your baby(optional).

Some tests also provide the option to screen for other conditions including screening the sex chromosomes (X/Y) for certain sex chromosomal conditions.

 

Our ultrasound scan is recommended with you NIPT test to check in on baby. The scan can confirm fetal viability, how far along the pregnancy is, and if the mother is having twin or multiple babies. We can also provide an estimated due date. 

 

 

What if I am having twins?

NIPT testing can typically be used for twin pregnancy and can even be used if the pregnancy is conceived with donated eggs. However it can not be performed for triplets/multiple pregnancies. 

 

 

What problems will this test NOT detect?

This test will not be able to detect structural abnormalities such as spina bifida, heart defects and growth problems. Please remember all NIPT tests are screening tests and not diagnostic tests. A screening test is one that is performed to identify those that have a higher chance or more likely to develop a specified disease or condition. It can not however provide confirmation and therefore those identified as having higher chance of a certain condition may need further diagnostic tests such as chorionic villus sampling (CVS) or amniocentesis. These diagnostic tests can identify a specific condition, disease or illness however unfortunately also carry a risk of miscarriage. 

 

Does NIPT replace diagnostic tests such as amniocentesis and chorionic villus sampling (CVS)?

NIPT tests do not replace prenatal diagnostic tests such as amniocentesis and CVS because they are different sort of tests. In general terms, non invasive prenatal tests screen for chromosome abnormalities in patients who do not have any medical evidence of a problems affecting their pregnancy at the time the test is taken. The test is carried out without directly sampling cells from the fetus or placenta. In contrast, amniocentesis takes cells from the amniotic fluid surrounding the baby, while CVS samples cells from the placenta. This process however is associated with a small risk of miscarriage. 

Invasive tests are usually performed later than NIPT. Non-invasive prenatal tests are very good at detecting abnormal number of copies of individual chromosomes, but some types of chromosome anomaly cannot be identified. Examples include triploidy and changes that alter the structure of chromosomes. Amniocentesis and CVS offer the possibility of generating a complete karyotype (picture), allowing additional types of abnormality to be detected. 

Amniocentesis or CVS would normally be an option if recommended by a doctor. Such tests would be used to determine if an abnormality was present when non-invasive tests such as NIPT have indicated a higher risk of an abnormality.

How and When will I get my results?

Blood Test:

The Scan Clinic have developed strong links with the NIPT providers which means our patients often get their results quicker than advertised. Depending on which NIPT test you opt for, they will be sent to the respective laboratory for testing and analysis (either UK or US). The lead time varies between 5 - 10 working days, however due to COVID-19 there can be a delay of a few additional days. In very rare circumstances the laboratory can take longer however in these exceptinal instances we will always endeavor to keep you updated.

The blood results will include the risk score and sex of your baby (if you opted for this at your appointment) and should be forwarded to your GP/ midwife for analysis and to be included in your maternity notes.

 

Ultrasound Scan:

If you choose NIPT Scan option then an ultrasound is also performed at your appointment. The ultrasound scan results are provided to you before you leave in the form of a written report and the verbal summary explained by one of NIPT specialist clinician. 

 

What if the test fails or does not give a result?

There is a very small chance the NIPT test fails to achieve a result, therefore a repeat sample would be needed to be collected. Test failure increases for IVF pregnancies, twin pregnancies, mothers using blood thinners and mothers with high BMI. 

One of the reasons why this may happen is that there is insufficient fetal DNA in the maternal blood sample to meet the minimum threshold of the specific NIPT test. This value varies between different tests from 2% required for the Neo NIPT test to around 4% for the Harmony test.

 

If there is no result from your initial test we would offer one free re-test.

 

 

How do I prepare for this test?

  • A full bladder may be required for the ultrasound scan test, therefore please drink 0.5 litres of fluid approximately 30 minutes before your scheduled appointment and please try your best not to empty your bladder before the examination.
  • An internal scan may be needed particularly in the early stages of your pregnancy. This may be offered at the start of the appointment instead of the scan over your tummy as it may give better information.
  • Please bring along your maternity folder with the results of any scans you have had and any other information relating to the pregnancy such as a referral.
  • We will require details of your GP / Health Care Professional, which may be requested before or at the time of the service.

 

 

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Neo 24 NIPT Test

  • Completely Safe for Mother and Pregnancy with no risk of miscarriage.
  • Potentially examine all 24 types of chromosomes
  • High detection rate for specific chromosomes abnormalities tested
  • Extremely low false-positive rate
  • Results in 5 days*
  • Far less 'no results' than other tests
  • Enhanced reassurance
  • from 10+ weeks 

 

The Neo 24 NIPT test is one of the latest non-invasive prenatal pregnancy screening tests available. The test is completely safe for mother and her unborn baby. The Neo 24 NIPT test will analyse the 24  chromosomes and enables assessment for a wide variety of chromosome abnormalities that can lead to a late miscarriage or the birth of a child with a serious congenital condition. Neo 24 offers a high detection rate for the specific chromosome abnormalities tested and a low false positive rate.

This test allows women who are at least 10 weeks gestation to be screened for chromosomal abnormalities. Neo 24 screening include:

  • Down's syndrome
  • Edwards syndrome
  • Patau syndrome
  • Turner syndrome
  • Klinefelter syndrome
  • XYY syndrome
  • Trisomy X syndrome

 

It is available for single including donor or surrogate and twin pregnancies. You can also choose to find out the sex of your baby**.  

 

The Neo 24 NIPT test involves a simple and safe blood test whereby a small quantity of blood is collected from the mother usually via a vein in her arm. The blood is then sent to the lab and analysed for cell free DNA (cfDNA), circulating fragments of fetal DNA. These are derived from the maternal placenta, the organ providing nutrition to baby, and are circulating in the mother's blood stream. The results determine if there is a high or low probability of baby having the conditions screened for. 

The Neo Test is processed and analysed in the UK. 

 

The Combined / Quad Tests Offered by the NHS?

The combined or nuchal screening test is offered by the NHS to all patients from 11-14 weeks pregnant and determines a background chance of the pregnancy being affected by certain conditions based on maternal age (Down's syndrome, Edwards' syndrome & Pataus' syndrome). The Quad test will also screen for these conditions and is offered to women who have missed the combined test appointment, presented late to the hospital or changed their mind about screening having initially declined the combined test, however the sensitivity of this test is lower than the combined test.

The combined test is time specific and can not be performed before 11 weeks or after 14 weeks pregnant. 

The background chance increases substantially for women who are 35 years of age and over.  This increases the likelihood of receiving a high chance result from these tests for these women. Therefore due to the limitations of this test the positive predictive value is reduced which means those women that are over 35 years of age are more likely to receive a high chance result, even if their baby does not have any of the conditions. 

Neo NIPT test has a higher positive predictive value as compared to the combined test/ Nuchal translucency screening test which means significantly lower high probability results where the condition is not actually present.

 

The Neo Test can be performed for the majority of pregnant women, however is particularly recommended for

  • parents who wish to avoid unnecessary invasive testing which carries a risk of miscarriage
  • women over 35 years of age
  • parents that have had a high probability result in their current or previous pregnancies 
  • confirmed chromosomal condition in a previous pregnancy

Please note that blood thinners can increase the possibility of receiving no results.

 

* Vast majority of results are within 5 working days.  

**Please note in some instances the Neo NIPT test may not be able to determine the sex.  In monochorionic (identical) twin pregnancies Harmony NIPT test can confirm the sex of each twin as it will be the same. For dichorionic (non identical) twin pregnancies Harmony can confirm if there are 2 girls, but can only confirm the presence of 1 boy.

 

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Harmony NIPT Test

The Harmony test is one of the leading and advanced non-invasive prenatal pregnancy screening tests avialable for parents wishing to determine the probability of their baby having Down's syndrome (Trisomy 21), Edwards' syndrome (Trisomy 18) or Patau's Syndrome (Trisomy 13).

The Harmony test is available from as early as 10 weeks into the pregnancy. It is available for single including donor or surrogate and twin pregnancies. You can also choose to find out the sex of your baby*.  

The Harmony test involves a simple and safe blood test whereby a small quantity of blood is collected from the mother usually via a vein in her arm. The blood is then sent to the lab and analysed for cell free DNA (cfDNA), circulating fragments of fetal DNA. These are derived from the maternal placenta, the organ providing nutrition to baby, and are circulating in the mother's blood stream. The results determine if there is a high or low probability of baby having one of the 3 screened conditions; Down's syndrome, Edwards' syndrome and Patau's syndrome. 

The Harmony Test is processed and analysed in the UK. 

 

The Combined Test, Nuchal Translucency (NT) Screening Tests Offered by the NHS

The combined or nuchal screening test is offered by the NHS to all patients and determines a background chance of the pregnancy being affected by certain conditions based on maternal age (Down's syndrome, Edwards' syndrome & Pataus' syndrome). The background chance increases substantially for women who are 35 years of age and over.  This increases the likelihood of receiving a high chance result from this test for these women. Therefore due to the limitations of this test the positive predictive value is reduced which means those women that are over 35 years of age are more likely to receive a high chance result, even if their baby does not have any of the conditions. 

The Harmony test has a higher positive predictive value as compared to the combined test/ Nuchal translucency screening test which means lower high probablility results where the condition is not actually present.

 

The Harmony Test can be performed for the majority of pregnant women, however is particularly recommended for

  • parents who wish to avoid unnecessary invasive testing which carries a risk of miscarriage
  • women over 35 years of age
  • parents that have had a high probability result in their current or previous pregnancies 
  • confirmed chromosomal condition in a previous pregnancy

Please note that blood thinners can increase the possibility of receiving no results.

 

*Please note in some instances the Harmony NIPT test may not be able to determine the sex.  In monochorionic (identical) twin pregnancies Harmony NIPT test can confirm the sex of each twin as it will be the same. For dichorionic (non identical) twin pregnancies Harmony can confirm if there are 2 girls, but can only confirm the presence of 1 boy.

 

Panorama NIPT Tests

 

 

Please note

  • Please bring your pregnancy book with previous scan results to your appointment as we will not be able to scan you without them.
  • All scans are performed to accomplish the main objective only.
  • Sometimes at the scan, we may not detect the heartbeat or can visualise the fetus on the screen. In such instances, this could be because it's too early for the ultrasound scan to detect the pregnancy or could indicate that a miscarriage has occurred. In the event of this happening, please be reassured that our trained staff are on hand to offer advice and guidance on next steps. 
  • The test can only be performed from 10 weeks gestational age. If the scan determines your pregnancy is earlier than 10 weeks you will be invited to book the NIPT blood test at the next available appointment when you are at least 10 weeks pregnant. 
  • Single ultrasound scan is included however any additional scans that may be required would be charged at £79 each.
  • Gender Determination is based on the NIPT DNA-blood test and is not conducted by ultrasound. There is no additional fee if this option is required.   
  • This ultrasound scan may involve internal scanning.
  • We may require details of your GP / Health Care Professional which will be requested from you before or at the time of your scan.
  • Our pregnancy scans do not replace or substitute any scan you have or will have with the NHS / maternity care provider.

 

 

Regular Price £
*Price is dependent on specific NIPT test booked.
Terms and Conditions apply.

Book Now

Call Me

Locations

Award Winning First class service from multi award winning clinic. Trusted Our experts are trusted by midwives, doctors and many different health professionals Convenient Convenient appointments to fit your schedule with our experts Rated Excellent rating on Google and WhatClinic Featured Featured in multiple publications including Huffington Post.