- Health Checks
- Blood Tests
✔ Harmony Prenatal Test is one of the most accurate non invasive DNA-based blood screening test for Down's Syndrome.
✔ Harmony Test has over 99% sensitivity for detection of Down's Syndrome, much more than traditional tests such as combined screening routinely offered.
✔ Harmony Prenatal Test can be performed from 10 weeks.
✔ Gender determination is optional and at no additional cost
✔ Results normally take 5-7 days
✔ This cutting edge, highly accurate test is not routinely available in the mainstream NHS maternity service.
✔ Early Viability Dating Scan with Report
✔ Harmony Blood test with Risk Results
✔ 2 Free 2D B&W Pictures
✔ No GP Referral Needed at London's Premier Clinic
Pregnancy must be
The harmony test is one of the latest and leading DNA based non invasive prenatal screening blood test with incredibly high sensitivity for estimating the risk of a fetus with Downs syndrome (a congenital disorder arising from chromosomal defect causing various physical and mental disability).
The harmony test is regarded as the most accurate screening tests available for Down's syndrome as compared to other traditional tests such as combined screening, which is currently the main method of screening for Down's syndrome offered in the mainstream NHS.
The test has:
Downs syndrome, also known as Trisomy 21, is a congenital disorder arising from a chromosomal defect during fetal development which causes various physical and mental disabilities. Down's syndrome is typically not inherited - it's simple the result of a one off genetic change in the sperm of egg. In every pregnancy there is a small chance of having a child with Down's syndrome, but the likelihood increases with the age of the mother.
The Harmony blood test involves taking a blood sample from the mother, just like a routine blood test. The mother must be at least 10 weeks into her pregnancy.
The blood sample is sent and analysed in a specialist laboratory where next generation sequencing techonology, coupled with advanced bioinformatics analysis will detect free floating fetal DNA (cfDNA), which is a marker in the mother's blood of baby's DNA. The resultant information will be generated into a detailed risk analysis report.
The test has:
This is a relatively new highly accurate alternative to the Downs Syndrome Screening Service provided by the NHS. It has been reported that 1 in 30 women can be given a high result with the NHS combined screening and are advised to undergo an invasive testing such as amniocentesis or chorionic villus sampling (CVS) to determine baby's chromosomal structure. These procedures carry a 1% risk of miscarriage. NIPT is a perfect risk free alternative as there is no risk of miscarriage from this non-invasive test. Furthermore NIPT carries the best detection rate of all screening tests and will detect over 99% of babies affected with Down's syndrome and other chromosomal abnormalities and less than 1 in 3000 women will be given high risk (false positive) screening test results.
Whilst the Harmony test or any other NIPT is NOT classed as a diagnostic test like amniocentesis or CVS it will give you the reassurance to the highest degree possible that you are making the right choices should you need further testing.
A scan is also performed in conjunction with the test to confirm fetal viability, how far along the pregnancy is, and if the mother is having twin or multiple babies. We can also provide an estimated due date.
The Harmony test can be used for twin pregnancy. It can even be used if the pregnancy is conceived with donated eggs.
It can not be performed for triplets/multiple pregnancy.
This test will not be able to detect structural abnormalities such as spina bifida, heart defects and growth problems.
Your blood will be transported to a UK based Harmony Approved pathology laboratory where they will be analysed and reported. Results for your test will be available in 5-7 days.
The Harmony test results take into account your age, pregnancy gestation and the DNA fraction in the blood sample. The results are shown on a report in a graphically format as either "low or high" risk for the different the trisomies.
The Harmony test is a screening test. A screening test is one that is performed to identify those that are at higher risk or more likely to develop a specified disease or condition. It can not however provide confirmation and therefore those identified as having higher risk may need further diagnostic tests. A diagnostic test is a procedure that can identify a specific condition, disease or illness.
This test screens for Down's syndrome and two other genetic conditions, trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). Therefore this test will give you information about the risk your baby has for these specific conditions.
As with all screening tests, false-positives and false negatives may occur however these are much lower in this test as compared to traditional tests available.
Should you have a high risk result you have the option for further diagnostic tests such as amniocentesis or chorionic villus sampling.
Does the Harmony blood test ever need to be repeated?
Occasionally there is insufficient fetal DNA in the blood sample obtained from mother to obtain a result. Therefore a repeat sample would be need to be collected. This occurs in about 2% of tests with overall no result rate of 3% (2% due to insufficient fetal fraction and 1% due to other reasons).
If there is a no result from your initial test we would offer one free re-test.
What is Included?
Harmony Blood test including Viablity & Dating Ultrasound Scan with reports and any measurements.
We offer a wide range of pregnancy ultrasound scans as well as blood profiles, please feel free to have a look over the complete range by following the quicklinks below.